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Discontinuation of Treatment with Cymbalta Discontinuation symptoms have been systematically evaluated in patients taking Cymbalta. Following abrupt discontinuation in MDD placebo-controlled clinical trials of up to 9-weeks duration, the following symptoms occurred at a rate greater than or equal to 2% and at a significantly higher rate in Cymbalta - treated patients compared to those discontinuing from placebo: dizziness; nausea; headache; paresthesia; vomiting; irritability; and nightmare. By and large I do believe the severity and incidence of side effects are lessening. I do feel like Im mostly thought not completely done with this drug. I think anyone worried about the withdrawal can take some comfort in my case, as I do seem to be getting better. At the moment I do believe I will make a full recovery from it. The process of withdrawal is just so amazingly It was a truly painstaking process of tapering down; at the end of the ramp-down I was literally taking capsules with two grains of the drug inside. And yet whenever I tried to speed things up I ended up feeling terrible. The ramp-down of somewhat over two months was completely necessary. And even then it was a difficult process. I am fortunate to have a job that gives me whole months off; I needed them.
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I came on this website for some clarity in dealing with my own situation, but I decided to leave my own comment. I have been on Cymbalta 60 mg for 14 months and I wish that I had been in a better mindset to have been able to decline this med. After an eval. I was diagnosed with depression and immediately prescribed this dosage. The first day I took cymbalta I experienced dizziness, vertigo, nausea, vomiting, blurred vision, chills, tremors, overall malaise, among other things. I asked my psych. if I could stop taking it and he said that my symptoms would worsen if I stopped. Eventually the symptoms disintegrated, and I felt normal again. If I took the meds on time I felt like myself. The min. I missed a dose the withdrawal symptoms kicked in which included but were not limited to chills, tremors, nausea, dizziness, vomiting, brain zaps, involuntary muscle spasms, etc. Now I want to get off of this cymbalta, b/c I feel I dont need it anymore and am ready to save some of that money and I have no idea what to do. My psych. tried weaning and the withdrawal symptoms were too horrid for me to handle. I am at a lost now, b/c I just want off of this medication!!!! My Mom, 84 yrs. old, has been taking Cymbalta for 3 months. She was admitted to the hospital approx 3 wks. ago for dehydration, acute bronchitus and beginning stages of pneumonia. Her blood levels were checked and discovered that her Coumadin level was 68! The norm is 5-7. The doctors in the ER were shocked, as were my Mom and I! The dr. said that had Mom fallen, she would have bled to death in 2-3 minutes and the ambulance could have never arrived in time.
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So glad other people shared of themselves. I went from 60 mg, to 30 for 7 days, then cold turkey. I made this decision because the doctors I work with agreed that longer tapering would prolong w/d; however, this w/d is so intense they wanted to hospitalize me. My doctors no longer prescribe this drug to patients and wish it would be taken off the market. Anonymous Because of the fibro, I had the dry mouth, sweating, and constipation symptoms pretty bad for the first few weeks. The sweating thing was so bad it went back and forth from chills to sweats, put me in bed for 4 days at one point and doctors thought I had a virus. right. I asked if Cymbalta could be the cause and was told no, unequivocally. Eventually I thought the sweats were just extra Hot Flashes, since Im that age. I figured the cymbalta didnt help them the way the prozac did inadvertantly, not the reason I took the prozac.
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The efficacy of Cymbalta as a treatment for depression was established in 4 randomized, double-blind, placebo-controlled, fixed-dose studies in adult outpatients 18 to 83 years meeting DSM-IV criteria for major depression. In 2 studies, patients were randomized to Cymbalta 60 mg once daily N123 and N128, respectively or placebo N122 and N139, respectively for 9 weeks; in the third study, patients were randomized to Cymbalta 20 or 40 mg twice daily N86 and N91, respectively or placebo N89 for 8 weeks; in the fourth study, patients were randomized to Cymbalta 40 or 60 mg twice daily N95 and N93, respectively or placebo N93 for 8 weeks. There is no evidence that doses greater than 60 mg/day confer any additional benefit. Cymbalta is not recommended for patients with end-stage renal disease or severe renal impairment estimated creatinine clearance 30 mL/min see WARNINGS AND PRECAUTIONS and Use In Specific Populations.
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Sheffrin M, Driscoll HC, Lenze EJ, Mulsant BH, Pollock BG, Miller MD, Butters MA, Dew MA, Reynolds CF 3rd. When Cymbalta and ethanol were administered several hours apart so that peak concentrations of each would coincide, Cymbalta did not increase the impairment of mental and motor skills caused by alcohol.
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Cymbalta is not universally tolerated nor free of safety risks, wrote Eli Lilly staff in the companys briefing documents posted on the FDAs website. However, the safety profile is well-characterized and not any different for chronic pain patients than it is for other patients who are already using the drug. Heres my theory of what happened: The meds were causing constipation, but I was never in discomfort so I didnt think anything of it. But I honestly feel now that due the constipation, my intestines were incapable of absorbing the nutrients I needed to function. So with the quality of the food and the right proportions of proteins/carbs/fats for my metabolism type slowly helping me feel better, I decided to start tapering off the Cymbalta. Foolishly, I thought I could just slowly reduce the dose and the time between between doses and be done in a week. All of us here know what happens next. I was feeling absolutely awful last week and finally decided to search the Internet for cymbalta withdrawal information. I found this board and was devistated for a couple of hours, then I got a sense of serious determination to beat this beast and take my life back from the drug companies. I took the advice mentioned here to begin to drink chamomile tea to help with the brain zaps. It absolutely made a difference! I ended up having 3 cups a day. After each cup I would get 2-4 hours of relief. And then the last couple of days, I started double-shotting my tea with two tea bags at a time. That also seemed to help. I have taken mega doses of niacin the last few weeks as a detox agent do your homework on that stuff first and this week added daily wheatgrass shots as an additional detox. Supplemental to all that has been to drink 1.5 liters of electrolyte water every day.
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Blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment see ADVERSE REACTIONS. You should also be aware of a dangerous metabolism issue that may affect you, and for which you should be tested before you take such a drug.
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Numerous cases of hyponatremia have been reported following treatment with a selective serotonin reuptake inhibitor SSRI. Risk factors for the development of SSRI associated hyponatremia including advanced age, female gender, concomitant use of diuretics, low body weight, and lower baseline serum sodium levels have been identified. Hyponatremia tends to develop within the first few weeks of treatment range 3 to 120 days and typically resolves within 2 weeks range 48 hours to 6 weeks after therapy has been discontinued with some patients requiring treatment, water restriction, dietary sodium. The proposed mechanism for the development of hyponatremia involves the syndrome of inappropriate secretion of antidiuretic hormone SIADH via release of antidiuretic hormone. You should not suddenly stop taking this medicine. Doing so may cause unpleasant side effects, including nausea and headache. If you wish or need to stop taking Cymbalta, your doctor will tell you how to reduce your dose gradually over time.
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In the Duloxetine clinical trials database, three Duloxetine-treated patients had liver injury as manifested by ALT and total bilirubin elevations, with evidence of obstruction. Substantial intercurrent ethanol use was present in each of these cases, and this may have contributed to the abnormalities seen. This list is not complete and other drugs may interact with duloxetine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
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The information in is not intended as a substitute for medical professional help or advice but is to be used only as an aid in understanding back pain and neck pain. Do not use duloxetine together with thioridazine Mellaril, or an MAO inhibitor such as furazolidone Furoxone, isocarboxazid Marplan, phenelzine Nardil, rasagiline Azilect, selegiline Eldepryl, Emsam, Zelapar, or tranylcypromine Parnate. A dangerous drug interaction could occur, leading to serious side effects.
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Eli Lilly and Company. Cymbalta R Significantly Reduced Osteoarthritis Knee Pain In New Study. Medical News Today. MediLexicon, Intl., 31 Jan. 2009. Web. Cymbalta duloxetine hydrochloride is an antidepressant marketed by Eli Lilly. It is a dual reuptake inhibitor of serotonin and norepinephrine.
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It is important to note that Cymbalta belongs to the Selective Serotonin and Norepinephrine Reuptake Inhibitors group. Therefore, abruptly stopping your Cymbalta dosage causes adverse body effects. To elaborate this more vividly, Serotonin affects the immune system, the renal system as well as the cardiovascular system. On the other hand Norepinephrine affects the blood transportation system, the nervous system and the heart beat system. duloxetine HCl is not for everyone. Do not take Cymbalta if you:
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Adults with MDD or co-morbid depression in the setting of other psychiatric illness being treated with antidepressants should be observed similarly for clinical worsening and suicidality, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Analyses of the relationship between treatment outcome and age, gender, and race did not suggest any differential responsiveness on the basis of these patient characteristics.
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Cymbalta withdrawal Insomnia - Sleeplessness caused by physical stress, mental stress or stimulants such as coffee or medications; it is a condition of being abnormally awake when one would ordinarily be able to fall and remain asleep. The world of today has witnessed many people experiencing stress, anxiety and depression. Fortunately, there are ways of dealing with these mental and body ailments. One sure way of doing that is by taking Cymbalta. This is a brand name for the generic anti-depressant drug: duloxetinean. Cymbalta has been widely used for treating mental and body ailments such as fibromyalgia, depressive disorder, anxiety disorder and diabetic neuropathy.
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Cymbalta withdrawal Toxic Epidermal Necrolysis - An abnormal condition where a large portion of skin becomes intensely red and peels off like a second-degree burn. Often the symptoms include blistering. Cymbalta withdrawal Gastrointestinal Hemorrhage - Stomach and intestinal excessive internal bleeding. Cymbalta withdrawal Grand Mal Seizures or Convulsions - A recurring sudden violent and involuntary attack of muscle spasms with a loss of consciousness. Minor Personal Injury, that was NOT life threatening, like a broken ankle
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